
| Posición | Ciudad | País | Homicidios | Habitantes | Tasa |
| 1 | San Pedro Sula | Honduras | 1,317 | 769,025 | 171.20 |
| 2 | Caracas | Venezuela | 3,797 | 3,273,863 | 115.98 |
| 3 | Acapulco | México | 883 | 847,735 | 104.16 |
| 4 | João Pessoa | Brasil | 620 | 780,738 | 79.41 |
| 5 | Distrito Central | Honduras | 928 | 1,195,456 | 77.65 |
| 6 | Maceió | Brasil | 733 | 1,005,319 | 72.91 |
| 7 | Valencia | Venezuela | 1086 | 1,527,920 | 71.08 |
| 8 | Fortaleza | Brasil | 2,541 | 3,818,380 | 66.55 |
| 9 | Cali | Colombia | 1,530 | 2,344,734 | 65.25 |
| 10 | São Luís | Brasil | 908 | 1,403,111 | 64.71 |
| 11 | Natal | Brasil | 931 | 1,462,045 | 63.68 |
| 12 | Ciudad Guayana | Venezuela | 536 | 862,720 | 62.13 |
| 13 | San Salvador | El Salvador | 1,067 | 1,743,315 | 61.21 |
| 14 | Cape Town | Sudáfrica | 2,244 | 3,740,026 | 60.00 |
| 15 | Vitoria | Brasil | 1074 | 1,884,096 | 57.00 |
| 16 | Cuiabá | Brasil | 467 | 827,104 | 56.46 |
| 17 | Salvador (y RMS) | Brasil | 2,129 | 3,919,864 | 54.31 |
| 18 | Belém | Brasil | 1,130 | 2,129,515 | 53.06 |
| 19 | ST. Louis | Estados Unidos | 159 | 318,416 | 49.93 |
| 20 | Teresina | Brasil | 416 | 840,600 | 49.49 |
| 21 | Barquisimeto | Venezuela | 601 | 1,293,693 | 46.46 |
| 22 | Detroit | Estados Unidos | 309 | 688,701 | 44.87 |
| 23 | Goiânia | Brasil | 633 | 1,412,364 | 44.82 |
| 24 | Culiacán | México | 384 | 910,564 | 42.17 |
| 25 | Guatemala | Guatemala | 1,288 | 3,074,054 | 41.90 |
| 26 | Kingston | Jamaica | 495 | 1,219,366 | 40.59 |
| 27 | Juárez | México | 538 | 1,347,165 | 39.94 |
| 28 | New Orleans | Estados Unidos | 150 | 378,715 | 39.61 |
| 29 | Recife | Brasil | 1518 | 3,887,261 | 39.05 |
| 30 | Campina Grande | Brasil | 153 | 402,912 | 37.97 |
| 31 | Obregón | México | 120 | 318,184 | 37.71 |
| 32 | Palmira | Colombia | 114 | 302,727 | 37.66 |
| 33 | Manaus | Brasil | 749 | 2,020,301 | 37.07 |
| 34 | Nuevo Laredo | México | 142 | 406,598 | 34.92 |
| 35 | Nelson Mandela Bay | Sudáfrica | 402 | 1,152,115 | 34.89 |
| 36 | Pereira | Colombia | 162 | 467,185 | 34.68 |
| 37 | Porto Alegre | Brasil | 1,442 | 4,161,237 | 34.65 |
| 38 | Durban | Sudáfrica | 1187 | 3,442,361 | 34.48 |
| 39 | Aracaju | Brasil | 312 | 912,647 | 34.19 |
| 40 | Baltimore | Estados Unidos | 211 | 622,104 | 33.92 |
| 41 | Victoria | México | 117 | 345,080 | 33.91 |
| 42 | Belo Horizonte | Brasil | 1,926 | 5,767,414 | 33.39 |
| 43 | Chihuahua | México | 289 | 868,145 | 33.29 |
| 44 | Curitiba | Brasil | 587 | 1,864,416 | 31.48 |
| 45 | Tijuana | México | 502 | 1,678,880 | 29.90 |
| 46 | Macapá | Brasil | 129 | 446,757 | 28.87 |
| 47 | Cúcuta | Colombia | 183 | 643,666 | 28.43 |
| 48 | Torreón | México | 330 | 1,186,637 | 27.81 |
| 49 | Medellín | Colombia | 657 | 2,441,123 | 26.91 |
| 50 | Cuernavaca | México | 168 | 660,215 | 25.45 |